Sunday, December 15, 2019

The Bioethics Debate Free Essays

Kristi Ellis Mrs. Scheidt English 1301. 174 11 October 2012 Paper #2 – The Bioethics Debate In â€Å"Patenting Life,† by Michael Crichton, and â€Å"Bioethics and the Stem Cell Research Debate,† by Robyn S. We will write a custom essay sample on The Bioethics Debate or any similar topic only for you Order Now Shapiro, they discuss gene patenting, medicine, stem cell research, and the laws of bioethics. According to Crichton and Shapiro, humans are all born with genes, stem cells, and organs that are part of our natural world, yet when the law tries to put limits on these rights it becomes unethical. Crichton and Shapiro both agree about the controversial issues surrounding science and medicine. They both point out the unethical issues, the innovation in medicine, and the impact on science and medicine in relation to the law. In both essays Crichton and Shapiro list many immoralities that arise out of bioethical issues. For instance, Crichton refers to an example of the Canavan disease in which the process to find a cure was halted due to gene patenting. It was a prime example of an issue that was unethical because the owner of the gene for the disease could choose whether or not to charge for a test and choose how much to charge for it, which blocks medical innovations. Crichton states, â€Å"There is no clearer indication that gene patents block innovation, inhibit research and put us all at risk† (432). Crichton goes on to say that genes are part of humans naturally and should not be privately owned (431). In comparison, Shapiro explains although embryonic stem cells give promise to the medical field, many ethical issues surround it such as the destruction of the embryo. Shapiro also writes that those who denounce embryonic stem cell research believe the embryo is already a human being with rights from conception, while others believe that human rights do not exist prior to birth (435). Additionally, medical advancement is critical for innovation in both essays. Crichton states that gene patenting prevents medical testing and slows medical advancement. Not only does it halt research, but it causes the costs of medical testing to rise because the owner can charge whatever he wants (431). He mentions doctors cannot get information on if a medication will or will not work on someone because the lack of quality tests. Crichton says â€Å"For years we’ve been promised the coming era of personalized medicine – medicine suited to our particular body makeup. Gene patents destroy that dream† (432). In contrast, Shapiro states that stem cells are important to the medical field because they can turn into a wide array of cell types that can help people with diseases such as diabetes, nervous system diseases, and Parkinson’s disease (434-35). In addition, he says stem cell research could provide important information on how human organs and tissues develop, which could lead to development of new medications (435). In both sources, the law plays a significant role in the unethical issues surrounding science and medicine. Crichton mentions how the United States Patent Office issued gene patents by mistake because of misinterpreted Supreme Court rulings. The issue of gene patents make it hard for people to donate their genes because most of the genes are privately owned (431). Crichton states that two congressman sponsored the genomic research and Accessibility Act, a bill that would ban patenting genes in nature (432). Shapiro denotes the growing importance of the law surrounding bioethical issues. He cites the United States Supreme Court cases of Roe v. Wade and Stenberg v. Carkart which dealt with a partial birth abortion law. Shapiro states, â€Å"In state courts, bioethical considerations inform judges’ balancing of patient healthcare confidentiality with a â€Å"duty to warn† of potentially dangerous patient behavior (433). The most significant law Shapiro cites is the Dickey Amendment which prohibits federal funding for embryo research (436). Shapiro mentions in addition to federal funding restrictions, many states have laws that limit embryonic stem cell research. Lastly, he cites the eligibility of federal patent protections significantly, the Thomson Patents (437). In conclusion, both Crichton and Shapiro can conclude the topics of gene patenting and embryonic stem cell research are unethical in some way. Although gene patenting blocks innovation and embryonic stem cell research promotes it, they both have laws that limit the impact on the world of science and medicine. According to Shapiro, â€Å"As these issues have moved to the center of public debate, the law has assumed an increasingly important place in the discipline of bioethics† (433). Thus, when the law puts limits on human genetics it becomes unethical and immoral according to both essays in this bioethical debate. WORD COUNT: 740 Works Cited Crichton, Michael. â€Å"Patenting Life. † Perspectives on Contemporary Issues: Readings Across the Disciplines. 6th ed. Ed. Katherine Anne Ackley. Boston: Wadsworth/Cengage Learning, 2012. 431-432. Print. Shapiro, S. Robyn. â€Å"Bioethics and the Stem Cell Research Debate. † Perspectives on Contemporary Issues: Readings Across the Disciplines. 6th ed. Ed. Katherine Anne Ackley. Boston: Wadsworth/Cengage Learning, 2012. 433-438. Print. How to cite The Bioethics Debate, Essay examples

Saturday, December 7, 2019

Difficulties faced By Spinelli Coffee-Free-Samples for Students

Question: Discuss about the difficulties faced by Spinelli Coffee. Answer: Introduction Coffee is regarded as one of the important traded commodities and is considered as one of the most vouched beverages around the world for its unique flavours along with sensory characteristics[1]. The following report is based on the Spinelli Coffee, one of the esteemed names in the contemporary coffee market[2]. The report starts via highlighting the limitations associated with the services of the company followed by a detailed highlight of companys history and environmental sustainable resources employed by them. Limitations of the Company The limitations of the company are reflected in regards to the services procured in terms of the corporate delivery. According to the official website of Spinelli Coffee, they require at least 3 to 4 hours excluding the day of order to process the bulk corporate order. Moreover, the orders of the food items are subject to the availability for of the stock[3]. These delays in delivery prevent Spinelli Coffee to compete with its immediate competitor in the contemporary market and that is Starbuck. Moreover, Spinelli Coffee is also at times criticised for its high level of price band. However, keeping their quality into consideration the nature of roosted process undertaken by them in order to maintain their original flavour of the coffee, their high price rate is justified. Background of the Company Spinelli Coffee is a San Francisco based company whose mission is to buy, sell and roast finest quality coffee. It was conceived in 1983 by Christopher Calkins and Arnold Spinelli and is famous among their market contemporaries for vending coffee to more than 20 different cafes, restaurants, hotels and food market. Its first outlet in Singapore opened in the year 1996 and this is followed via rigorous strategic expansion in different business district including the downtown shopping malls. Approaches the company adopted to be environmentally sustainable Caffeine is naturally occurring alkaloids which acts as mild stimulant and often are physiologically active in human. It is one of the widely used psychoactive drugs and is a mild stimulant effect to the central nervous system[4]. The percentage of caffeine present in coffee differs by brand. However, in average share of caffeine in coffee as traded by few of the common brands lies in between 30 to 40 mg/bag of coffee. Solvents like methyl chloride, chloroform, acetone, ethyl acetate and ethanol are some of the popularly used solvent extraction methods that are reduce to reduce the caffeine content of the coffee[5]. The solvent extraction method is carried out via adding a sudden percentage of solvent in the coffee. Caffeine is comparatively more soluble in solvent than that of coffee and hence seperates out of the coffee via getting dissolved inside the solvent. The solvent containing caffeine is either evaporates or left behind to get mixed with the environmental water bodies. This kind of process of solvent extraction of caffeine is considered to be hazardous for the atmosphere because their presence in the product as well their discharge into environment can serious threat towards the health of mankind. In order to reduce the harmful impact of the solvent extraction method over the environment and on the coffee consumers, the Spinelli Coffee employs Swiss Water process for the caffeine extraction. It only uses water for the process of decaffeination of the coffee and thereby making the decaffeinated coffee 100% chemical free[6]. According to Vuong et al. (2014), Roach, water is environment friendly and thus regarded as safe solvent for decaffeination. It is also cost-effective and more accessible relative to other organic solvents. Hence it can be regarded as a solvent for choice for the isolation and separation of the caffeine. Furthermore, the advantage of Swiss water process in decaffeination is, it helps to generate pure decaffeinated coffee beans that is free from harmful chemicals while keeping the original flavour intact[7] References Preedy, Victor R., ed.Coffee in health and disease prevention. Academic Press, 2014. Shinde, Ms RR, and N. H. Shinde. "Extraction of Caffeine from Coffee and preparation of Anacin drug."International Journal of Engineering10, no. 1: 2017. Spinelli Coffee Company. 2017.Spinelli Coffee Company. https://www.spinellicoffee.com/swiss-water-decaffeination. Spinelli Coffee Company. 2017.Spinelli Coffee Company. https://www.spinellicoffee.com/corporate-delivery. Spinelli Coffee Company. 2017.Spinelli Coffee Company. https://www.spinellicoffee.com/about-us. Vuong, Quan V., and Paul D. Roach. "Caffeine in green tea: its removal and isolation."Separation Purification Reviews43, no. 2 (2014): 155-174 Vuong, Quan V., and Paul D. Roach. "Caffeine in green tea: its removal and isolation."Separation Purification Reviews43, no. 2 (2014): 155-174. Spinelli Coffee Company. 2017.Spinelli Coffee Company. https://www.spinellicoffee.com/about-us. Spinelli Coffee Company. 2017.Spinelli Coffee Company. https://www.spinellicoffee.com/corporate-delivery. Preedy, Victor R., ed.Coffee in health and disease prevention. Academic Press, 2014. Shinde, Ms RR, and N. H. Shinde. "Extraction of Caffeine from Coffee and preparation of Anacin drug."International Journal of Engineering10, no. 1: 2017. Spinelli Coffee Company. 2017.Spinelli Coffee Company. https://www.spinellicoffee.com/swiss-water-decaffeination. Vuong, Quan V., and Paul D. Roach. "Caffeine in green tea: its removal and isolation."Separation Purification Reviews43, no. 2 (2014): 155-174.

Saturday, November 30, 2019

Lucid Dreaming Essays (1051 words) - Dream, Lucid Dreams

Lucid Dreaming Ever have the feeling where you don't really know if you are dreaming or awake? That feeling of conscious awaking in you dreams where you are able to control yourself, your movements, and your wishes. This can be defined as lucid dreams. Roughly one-third of our lives we spend on sleeping, and significant amount of this time is spent on dreaming. So why not enjoy our dreams by controlling them, instead of letting dreams controlling us. The term "lucid", came from Frederik Van Eeden in 1913, he used it to define the sense of mental clarity. The definition of lucid dreaming is nothing more than becoming aware that you are dreaming, while you are dreaming. There are different levels of control among people where you are able to control your lucid dreams. A low-level lucid dream is one where you know you're dreaming, but that's it. In experiencing a higher level of lucid dream, you have the power to control, influence, and react to various events and contents of the dream. For those who have mastered the state of lucidity, the benefits are enormous. It gives a person a chance to experience adventures unsurpassed in everyday life, like that vacation on the moon. You can literally do anything you wish; the only limits are the limits bound my your imagination. Having the ability to tap to our unconscious, and subconscious mind, it also gives us a valuable insight into our daily lives. "By learning to make the best of the worst situation imaginable, you can overcome nightmare's and fears in the waking world" Gackenback/Bosveld 1989) There are several techniques for inducing a lucid dream, and the Lucidity Institute, Inc., founded in 1987 by lucid dreaming researcher Dr. Stephen LaBerge to support research on lucid dreams and to help people learn to use them to enhance their lives. This has created special devices to assist people in achieving lucid dreams. Inducing lucid dreams takes concentration, effort, and time. Some people have been able to have lucid dreams on the very first night of attempting to do so, however it may take others up to weeks. This varies greatly from person to person. It seems, as people who remember their dreams with greater ease tend to find it easier to have lucid dreams when compared to those who remember only a few every month (LaBerge). Many people seem to confront with the chance to learn of lucid dreaming asking themselves, "Why would I want to lucid dream?" The most common use of lucid dream is for those who have achieved the skill for pure fun and adventure. Unlike reality the laws of physics or even the rules of government do not restrict you. There is no need to be afraid of social consequences, because they are non-existent. You can fly, glide, touch, taste, whatever your heart desires. The limits are limitless. "Entertainment is not the only use of lucid dreaming, because of the strong link between the mind and body during dreams, there is evidence to suggest that dreams can be used for mental and physical healing" (Ziesing). Many have failed trying to induce lucid dreams, yet often people start having a lucid dream after giving up. So do not push to have one, trying too hard would only end up in frustration. After one has accomplished with the task of inducing lucid dreams to the max, reality testing is the assurance, and a constant question. Whether or not what one is experiencing is indeed reality, several times a day one may ask him/her self, "Am I dreaming?" The answer to that question might surprise the inducer of lucid dreams in time (Van de Castle 42). Mnemonic Induction of Lucid Dreams (MILD) is a technique developed by Dr. Stephen Laberge, and is used by him to induce lucid dreams at will during his study. The steps to lucid dreaming via MILD are to set you mind to awaken from dreams and recall them as completely as possible. After one has recalled it, concentrating single-mindedly on its intention to remember to realize that he/she was only dreaming. One may say, "Next time I'm dreaming, I want to remember I'm dreaming." By trying to really put this really in your mind and

Tuesday, November 26, 2019

Modeling Meiosis Lab Lesson Plan

Modeling Meiosis Lab Lesson Plan Sometimes students struggle with some concepts that relate to evolution. Meiosis is a somewhat complicated process, but necessary to mix up genetics of offspring so natural selection can work on a population by choosing the most desirable traits to be passed down to the next generation. Hands-on activities can help some students grasp the concepts. Especially in cellular processes when it is difficult to imagine something so small. The materials in this activity are common and easily found. The procedure does not  rely on expensive equipment like microscopes or take up a lot of space. Preparing for Modeling Meiosis Classroom Lab Activity Pre-Lab Vocabulary Before starting the lab, make sure students can define the following terms: MeiosisChromosomeCrossing OverHaploidDiploidHomologous PairGametesZygote Purpose of the Lesson To understand and describe the process of meiosis and its purpose using models.   Background Information   Most cells in multicellular organisms like plants and animals  are diploid. A diploid  cell has two sets of chromosomes that form homologous pairs.  A cell with only one set of chromosomes are considered haploid. Gametes, like the egg and sperm in humans, are examples haploid. Gametes fuse during sexual reproduction to form a zygote which is once again diploid with one set of chromosomes from each parent. Meiosis  is a process that starts with one diploid cell and creates four haploid cells. Meiosis is similar to mitosis and must have the cells DNA replicate before it can begin. This creates chromosomes that are made up of two sister chromatids connected by a centromere. Unlike mitosis, meiosis requires two rounds of division to get half the number of chromosomes into all of the daughter cells.  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Meiosis begins with meiosis 1 when homologous pairs of chromosomes will be split.  The stages of meiosis 1 are similarly named to the stages in mitosis and also have similar milestones: prophase 1: homologous pairs come together to form tetrads, nuclear envelope disappears, spindle forms (crossing over may also happen during this phase)metaphase 1: tetrads line up at the equator following the law of independent assortmentanaphase 1: homologous pairs are pulled aparttelophase 1: cytoplasm divides, nuclear envelope may or may not reform The nuceli now only have 1 set of (duplicated) chromosomes. Meiosis 2 will see the sister chromatids split apart. This process is just like mitosis. The names of the stages are the same as mitosis, but they have the number 2 after them (prophase 2, metaphase 2, anaphase 2, telophase 2). The main difference is that the DNA does not go through replication before the start of meiosis 2. Materials and Procedure You will need the following materials: String4 different colors of paper (preferably light blue, dark blue, light green, dark green)Ruler or Meter StickScissorsMarker4 paper clipsTape Procedure: Using 1 m piece of string, make a circle on your desk to represent the cell membrane. Using a 40 cm piece of string, make another circle inside the cell for the nuclear membrane.Cut 1 strip of paper that is 6 cm long, and 4 cm wide from each color of paper (one light blue, one dark blue, one light green, and one dark green) Fold each of the four strips of paper in half, lengthwise. Then place the folded strips of each color inside the nucleus to represent a chromosome before replication. The light and dark strips of the same color represent homologous chromosomes. At one end of the dark blue strip write  a large B (brown eyes) on the light blue make a lower case b (blue eyes). On the dark green at a tip write T (for tall) and on the light green write a lower case t (short)Modeling interphase: to represent DNA replication, unfold each paper strip and cut in half lengthwise. The two pieces that result from cutting each strip represent the chromatids. Attach the two identical chromati d strips at the center with a paperclip, so an X is formed. Each paper clip represents a centromere.4 Modeling prophase 1:  remove the nuclear envelope and put it aside. Place the light and dark blue chromosomes side by side and the light and dark green chromosomes side by side.  Simulate crossing over by measuring and cutting a 2 cm tip for a light blue strip that includes the letters you drew on them earlier. Do the same with a dark blue strip. Tape the light blue tip to the dark blue strip and vice versa. Repeat this process for the light and dark green chromosomes.Modeling metaphase 1: Place four 10 cm strings inside the cell, so that two strings extend from one side into the center of the cell and two strings extend from the opposite side into the center of the cell. The string represents the spindle fibers. Tape a string to the centromere of each chromosome with tape. Move the chromosomes to the center of the cell. Make sure that the strings attached to the two blue chromosomes  come from opposite sides of the cell (same for the two green chromosomes).  Modeling anaphas e 1: Grab onto the ends of the strings on both sides of the cell, and slowly pull the strings in opposite directions, so the chromosomes move to opposite ends of the cell. Modeling telophase 1: Remove the string from each centromere. Place a 40 cm piece of string around each group of chromatids, forming two nuclei. Place a 1 m piece of string around each cell, forming two membranes. You now have 2 different daughter cells. MEIOSIS 2 Modeling prophase 2: Remove the strings that represent the nuclear membrane in both cells. Attach a 10 cm piece of string to each chromatid.Modeling metaphase  2:   Move the chromosomes to the center of each cell, so they are lined up at the equator. Make sure the strings attached to the two strips in each chromosome come from opposite sides of the cell.Modeling anaphase  2: Grab onto the strings on both sides of each cell, and pull them slowly in  opposite directions. The strips should separate. Only one of the chromatids should have the paper clip still attached to it.Modeling telophase  2: Remove the strings and paper clips. Each strip of paper now represents a chromosome. Place a 40  cm. piece of string around each group of chromosomes, forming four nuclei. Place a 1m string around each cell, forming four separate cells with only one chromosome in each.    Analysis Questions Have students answer the following questions to understand the concepts explored in this activity. What process did you model when you cut the strips in half in interphase?What is the function of your paper clip? Why is it used to represent a centromere?What is the purpose of placing the light and dark strips of the same color side by side?How many chromosomes are in each cell at the end of meiosis 1? Describe what each part of your model represents.What is the diploid chromosome number of the original cell in your model? How many homologous pairs did you make?If a cell with a diploid number of 8 chromosomes undergoes meiosis, draw what  the cell looks like after Telophase 1.What would happen to an offspring if cells did not undergo meiosis before sexual reproduction?How does crossing over change diversity of traits in a population?Predict what would happen if homologous chromosomes did not pair in prophase 1. Use your model to show this.

Friday, November 22, 2019

Breast Cancer

Breast Cancer Essay INCIDENCE Breast Cancer Essay is the most common malignancy among women and has the highest fatality rate of all cancers affecting this sex. It is the leading cause of death among women aged 35-54. In 1999 an estimated 175,000 women were diagnosed with breast cancer. That is one woman every three minutes. At the same time 43,000 will die, at the rate of one every two minutes. The incidence of men diagnosed with breast cancer is rare, however it does occur. Approximately 1,300 men a year are diagnosed, and 400 die annually due to the disease. A total of 75% of all breast cancers occur in women with no known risk factors. 80% of breast cancers occur in women aged 50 and up. The mortality rate would decrease if every woman over 50 was informed and followed guidelines. When confined to the breast, the survival rate is 95%. Studies have shown that more white women than black women get breast cancer, however more black women die of breast cancer because they are not diagnosed at an early stage. SIGNS AND SYMPTONS Most breast cancers appear as a slowly growing, painless mass, though a vague discomfort may be present. Physical signs include a retracted nipple, bleeding from the nipple, distorted areola or breast contour, skin dimpling over the lesion, attachment of the mass to surrounding tissues including the underlying fascia and overlying skin, and enlarged lymph nodes. In most advanced stages of the disease the skin nodules with ultimate breakdown and ulcer formation may be seen. Metastases should be sought immediately so that further spread will not be a factor. Among the common sites of metastases are the lungs and pleura, the skeleton (specifically the spine, pelvis, and skull), and the liver. Whenever possible, distant spread of the disease should be confirmed by a lymph nose biopsy, by x-ray, or by liver and bone scans using radioactive isotopes. WHO IS AT RISK? All women and men are at risk of getting breast cancer. However personal history with family members having breast cancer adds an increase to the risk factor. Contradictory to this though studies have shown that 75% of breast cancer occurs in women with no history and no known risk factors. Not ever having children, or having ones first child after 30 yrs., also increases the risk of breast cancer in women. Heavy alcohol abuse is a risk factor as well. Studies have also shown that women who began menstruation early, twelve years or less, and women who began menopause late, fifty-five years plus, also have a greater risk of breast cancer. PREVENTION There are three ways to attempt to detect prevention, however since there is no cure, one cannot determine what actions to take to prevent. The most common technique for early detection is by a regular doctors examination. The second technique at detecting breast cancer is by a breast self-examination (BSE), and lastly, by mammogram. BSE should begin when a woman is eighteen or older, so that the breast is fully developed. During the BSE women should begin to learn what is normal and what is not in their breasts. Mammography is the best method at detecting breast cancer. A woman should have a mammogram when she is 40 yrs. old, and then one every two years until she is 50 yrs. old. Once a woman is 50 yrs. old she should have a mammogram annually because as ones age increases, so does the risk of getting breast cancer. Many women also need to be educated about the risks of breast cancer and how to detect it early. The majority of women with breast cancer do not know about the fortunateness of detecting breast cancer early, never mind follow the detection guidelines. TREATMENT Therapy depends mainly on the extent of the disease and the patients age. If there is evidence of wider metastasic spread, treatment will be palliative. This means that treatment will lessen the severity of pain, however it will not cure. READ: Israel Economy Essay When there is no evidence of spread, the treatment of choice is total mastectomy and modified radical mastectomy. This is an entire or partial removal of the affected breast. In the best circumstances, the 10 yr. .

Wednesday, November 20, 2019

What is peak oil Is there any evidence that cities in the developing Essay

What is peak oil Is there any evidence that cities in the developing world are taking the issue seriously in their planning If there is little or no evidence, why is this the case - Essay Example st of the potentially oil rich regions have already been explored, and also due to legislation concerning the preservation of land with natural beauty or heritage value. The irreversible decline in oil production will cause adverse impacts in the global economy, â€Å"recession, food shortages and wars and conflicts over the remaining oil supplies† (Huddart and Stott 873). By the year 2030, it is predicted that while city dwellers in developed countries would have increased by 20%, the urban population in developing countries would have more than doubled to around 4 billion people, leading to overcrowding in several cities. In contemporary society there is a heavy dependence on oil for transportation, in industry, and in other requirements for liquid fossil fuels. â€Å"China, India and other countries are rapidly increasing their consumption while production from known oil fields is peaking† (Wissler 80). Kenneth S. Deffeyes (23) raises a controversial perspective based on geology and mathematics; he considers it improbable that additional major oilfields now remain undiscovered, and predicts increasingly difficult economic, social and political conditions particularly for regions most dependent on oil, specifically imported oil. Saudi Arabia, Kuwait and other exporters of oil will be able to charge high rates to fulfill the demands for the commodity, resulting in steep oil price hikes followed by greater chaos than similar occurrences in 1973 and 1979. The problem of ‘peak oil’ is also related to the issue of global warming. When oil production peaks and starts declining, it will be necessary to use other substitutes besides renewable resources examined above, such as coal. This will be necessary to power electric and hybrid vehicles and as the material converted into diesel fuel. These processes producing carbon dioxide will increase air and water pollution, and adversely affect climate change. â€Å"Therefore, a potential effect of climate change is increased

Tuesday, November 19, 2019

Live Performance versus Studio Recordings Essay Example | Topics and Well Written Essays - 500 words

Live Performance versus Studio Recordings - Essay Example These differences are highly noticeable in a studio vs. live recording of the Beatles’ ‘Love Me Do’. The live recording was captured at the BBC, while the studio recording was featured on the album ‘Please, Please, Me’. One of the advantages of studio recordings is that the band and the producer have the luxury of recording the different musical elements at different times and then mixing them together. This ensures that the greatest quality recording is possible. This is definitely noticeable with the Beatles’ studio recording as one notices the crisp drums and harmonica sound that is produced from the song’s introduction. Just as instruments can be recorded on different tracks, so can vocals. This is a highly noticeable feature for the Beatles’ music as they are prone to singing in harmony. As the harmony begins one again recognizes the pure crisp sound they are able to achieve. Undoubtedly this sharp sound was achieved through many hours in a studio perfecting the exact vocal elements of the song. There is the recognition that while the studio environment is able to achieve a sharp and crisp sound, the live environment is generally more free-form. In this way, the live environment lacks the ability to record the instrumentation and vocals separately and as such may contain some errors. While this rough sound may perturb some, for others live recordings may be fuller of life as they constitute a singular performance. The Beatles’ BBC performance of ‘Love Me Do’ contains many of these elements. While the harmonica and drum track of the studio recording achieve a high level of musicianship, one recognizes that there is a messier and rough feel in the BBC track. While the Beatles are consummate musicians, one recognizes this difference is slight; however it functions as one of the major differing elements between the songs. In terms of vocal elements, it appears that the studio recording was more